靶向免疫治疗联合放射治疗在晚期黑色素瘤中的研究进展/The research advance of targeted immunotherapy combined with radiotherapy for the stage III/IV melanomas
Xiaomei LUO, Jibing CHEN, Lizhi NIU et al.
【摘要】黑色素瘤是皮肤癌中最具侵袭性、死亡率较高的恶性肿瘤。Ⅰ、Ⅱ期黑色素瘤采取手术切除可完全治愈，Ⅲ、Ⅳ期黑色素瘤应用传统的手术、放化疗方案治疗效果不理想，预后差。近年来，随着对Ⅲ、Ⅳ期黑色素瘤治疗方案的探索，靶向免疫治疗取得了显著疗效。靶向免疫药物可抑制负性调节因子，增强全身抗肿瘤免疫效应。放疗在杀死局部肿瘤的同时，也可增强全身免疫应答。近期研究发现，靶向免疫联合放射治疗可增强对肿瘤局部和远处的控制作用，延长患者总体生存期，两者联合治疗优于单一治疗方案。本文就上述研究领域内的进展作一综述。
【关键词】靶向免疫治疗 放射治疗 黑色素瘤联合治疗
[Abstract] Melanoma is the most aggressive, lethal malignant tumor in skin cancers. Stage I/II melanomas can be cured by operation resection, but the treatment effects of traditional operation, chemotherapy and radiotherapy are not ideal to the stage III/IV melanomas. Stage III/IV melanomas are of the most ineffectively-treated tumors, and the prognosis is very poor. In recent years, much more advanced was made in the exploration of targeted immunotherapy, which can inhibit the negative regulatory factors, enhance the systemic anti-tumor immune effect. Radiotherapy not only kill tumor cell, but also enhance systemic immune response at the same time. Recently studies have shown that, targeted immunotherapy combined with radiotherapy can promote the control effect on local and distant tumor, prolong the overall survival time; the synergistic effect of these two therapy are superior to single therapy. This review summarized the progress of these research field.
[Keywords] Targeted immunotherapy; Radiotherapy; Melanoma; Synergistic effect
