冷冻消融联合DC-CIK 免疫疗法治疗转移性肝细胞癌回顾性分析/Combination treatment with comprehensive cryoablation and immunotherapy in metastatic hepatocellular cancer
Long Xin'an, Yao Fei, Zeng Jianying et al.
【摘要】
目的：对转移性肝癌患者冷冻消融联合DC-CIK免疫治疗疗效进行回顾性分析。
方法：45例转移性期肝癌患者，根据治疗方式分为冷冻联合DC-CIK 治疗组（21 例），冷冻治疗组（12 例），DC-CIK 治疗组（5 例）和未治疗组（7 例）。对各组患者进行随访，分析各组患者总体生存期。
结果：各组患者中位生存时间分别为：冷冻联合DC-CIK 治疗组32 个月，冷冻治疗组17.5 个月，DC-CIK 治疗组4 个月，未治疗组3 个月，冷冻联合DC-CIK 治疗组患者总体生存期显著长于未治疗组、冷冻组和DC-CIK 治疗组。结论 冷冻联合 DC-CIK 免疫治疗显著延长转移性肝癌患者总体生存期。
【关键词】 冷冻外科手术； DC-CIK； 免疫疗法； 转移性肝癌
[Abstract]
Objective To retrospectively assess the effect of comprehensive cryosurgery (ablation of intra- and extrahepatic tumors) plus dendritic cell-cytokine-induced killer cell immunotherapy in metastatic hepatocellular cancer.
Methods 45 patients were enrolled and divided into four groups based on their treatment method: cryo-immunotherapy(21 patients), cryotherapy(n＝12), immunotherapy(n＝5) and untreated(n＝7) groups. Overall survival(OS) of these 4 groups metastatic hepatocellular cancer patients was assessed after an 8-year follow-up. Results Median OS was higher following cryo-immunotherapy (32 months) or cryotherapy(17.5 months; P＜0.05) than in the untreated group(3 months) and was higher in the cryo-immunotherapy group than in the cryotherapy group(P＜0.05).
Conclusion Cryotherapy and, especially, cryo-immunotherapy significantly increased OS in metastatic hepatocellular cancer patients.
[Key words] Cryosurgery; Dendritic cell-cytokine-induced killer cell; Immunotherapy; Metastatic hepatocellular
冷冻消融联合DC-CIK免疫疗法治疗转移性肝细胞癌回顾性分析.pdf