肝癌患者冷消融后部分生化指标和前炎症因子的变化/The change of partial biochemical parameters and pro-inflammatory cytokines of hepatic carcinoma patients treated with cryoablation therapy
ZHOU Hong tao, NIU Lizhi, ZHOU Liang et al.
【摘要】
目的 探讨肝癌患者冷消融前后部分生化指标及前炎症因子的变化。
方法 20例不适合手术的肝癌患者接受冷消融治疗, 检测患者术前, 术后1、3、7 d的血清谷丙转氨酶( ALT)、谷草转氨酶( AST) 、总胆红素( TBIL)、肌红蛋白(M y)、肌酐( C r)、肿瘤坏死因子-a( TNF-a)和白介素-6( IL-6)值, 并进行比较。
结果 肝癌患者冷消融术后1 d与术前相比, 上述指标均显著升高; 术后3 d开始明显降低; 术后7 d与术前相比, ALT、AST、My 和Cr无显著差异, TBIL、TNF-a和IL-6仍有不同程度升高。
结论 肝癌冷消融治疗对肝肾功能的影响及前炎症细胞因子虽为一过性的, 但仍需防止因前炎症细胞因子大量释放导致的副作用。
【关键词】 肝癌; 冷消融; 生化指标; 肿瘤坏死因子-a; 白介素-6
[Abstract]
Objective To explore the change of partial biochemistry parameters and pro-inflamm atory factors of hepatic cancer patients treated w ith cryoab lation therapy.
Methods Twenty unsuitable for traditional surgery hepatic cancer patients treated with cryoablat ion therapy. Serum levels of ALT, AST, TBIL, My, Cr, TNF-a and IL-6 of pre-treatment, 1 d, 3 d and 7 d of post-treatment were tested and analyzed.
Results All levels of parameters o f 1 d-post-treatment were significantly higher than those o f pre-treatment; declined notably on 3 d-post-treatment; no significant difference was observed between 1 d-pre-treatment and 7 d-post-treatment in levels of serum ALT, AST, My and Cr, while levels of TNF-a, TB IL and IL-6 o f 7 d-post-treatment still remained at higher levels.
Conclusion Renal function and pro inflammatory cytokines caused by cryoablation for hepatic cancer patients, butmeasures still need to prevent adverse reactions occurring caused by too much pro inflammatory factors releasing.
[Key words] Hepatic cancer; Cryoablation; Laboratory marker; Tumor necrosis factor-alpha; Interlukin-6
